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Evania M 5/500mg Tablet
Evania M 5/500mg Tablet
Empagliflozin:
- An SGLT2 (Sodium-Glucose Co-Transporter 2) inhibitor.
- Reduces glucose reabsorption in the kidneys, increases urinary glucose excretion, and lowers blood glucose levels.
Metformin Hydrochloride:
- A biguanide antihyperglycemic agent.
- Reduces basal and postprandial glucose levels by decreasing hepatic glucose production, improving insulin sensitivity, and increasing peripheral glucose utilization.
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✅ Description:
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✔️ Evania-M Tablet is indicated for the treatment of adults with type 2 diabetes mellitus as an adjunct to diet and exercise in the following situations:
- Inadequate control on Metformin alone: For patients not sufficiently controlled on their maximally tolerated dose of Metformin.
- Combination therapy: In combination with other antidiabetic medications in patients not controlled with Metformin and these medications.
- Pre-existing combination therapy: For patients already on Empagliflozin and Metformin as separate tablets.
✔️ Side Effects
Empagliflozin:
- Common: Urinary tract infections, genital mycotic infections, thirst, increased urination.
- Rare: Diabetic ketoacidosis, Fournier’s gangrene.
Metformin:
- Very common: Gastrointestinal disturbances, hypoglycemia (with sulfonylureas or insulin).
- Rare: Lactic acidosis, vitamin B12 deficiency.
✔️ Dosage & Administration
- Individualized dosage: Based on patient response and tolerability.
- Administration: Take twice daily with meals. Gradual dose escalation is recommended to minimize gastrointestinal side effects.
Maximum daily doses:
- Metformin Hydrochloride: 2000 mg.
- Empagliflozin: 25 mg.
- Switching from Metformin alone: Start with Empagliflozin 5 mg and a similar total daily dose of Metformin.
- Switching from Empagliflozin alone: Start with Metformin Hydrochloride 500 mg and a similar total daily dose of Empagliflozin.
- Current combination therapy: Use the same total daily doses of Empagliflozin and Metformin as in existing therapy.
- Volume-depleted patients: Correct dehydration before initiating therapy.
- Renal impairment: Contraindicated in patients with an eGFR <45 mL/min/1.73 m².
- Pediatric patients: Not recommended for patients under 18 years.
✔️ Interaction
- Diuretics: May increase volume depletion risks.
- Insulin or insulin secretagogues: Increased risk of hypoglycemia.
- Drugs reducing Metformin clearance (e.g., ranolazine, cimetidine): Increased risk of lactic acidosis.
- Alcohol: Potentiates the effect of Metformin on lactate metabolism. Avoid excessive alcohol consumption.
✔️ Contraindications
- Hypersensitivity to Empagliflozin or Metformin.
- Acute metabolic acidosis (e.g., lactic acidosis, diabetic ketoacidosis).
- Severe renal failure (GFR <30 mL/min).
- Acute conditions affecting renal function (e.g., dehydration, severe infection, shock).
- Hepatic impairment or alcohol abuse.
✔️ Pregnancy & Lactation
- Pregnancy: Potential risks to the fetus during the second and third trimesters. Use only if benefits outweigh risks.
- Lactation: Not recommended as it is unclear if the components are excreted in breast milk.
✔️ Precautions & Warnings
- Lactic acidosis: Rare but serious. Immediate discontinuation and hospital treatment are required if suspected.
- Hypotension: Monitor for symptoms, especially in elderly or volume-depleted patients.
- Ketoacidosis: Evaluate patients with metabolic acidosis symptoms promptly.
- Renal function: Monitor regularly; discontinue if acute kidney injury occurs.
- Infections: Increased risk of urinary and genital infections. Treat promptly if symptoms occur.
- Vitamin B12 deficiency: Monitor annually.
✔️ Storage:
- Store below 30°C.
- Protect from light and moisture.
- Keep out of the reach of children.
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everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
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and discuss all your queries related to any disease or medicine. We
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